Thiohydantoin and quinolone derivatives have attracted researchers' attention because of a
broad spectrum of their medical applications. The aim of our research was to synthesize and …

Aim: A novel series of fused benzochromenes with expected cytotoxicity and HIF-1α
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …

A series of novel heterocyclic structures, namely 1, 3‐oxazines, 1, 3‐thiazines and 2, 4‐
diaminopyrimidines, were designed and synthesised. The bioassay tests demonstrated that …

Acetyl-3-cyano-6-methyl-4-styryl/(4-methxphenyl) pyridine-2 (1 H)-thiones (IIa),(IIb) were
synthesized via reacting ylidenecyanothioacetamides (Ia),(Ib) with acetylacetone. Treatment …

One-pot reactions offer advantages like easy automation, higher product yields, minimal
waste generation, operational simplicity, and thus reduced cost, time and energy. This …

Anti-cancer activities of some pyrano-pyridines have been previously reported. Herein, we
investigated antiproliferative and apoptotic effects of the novel pyrano [3, 2-c] pyridine (PP …

As a continuation of our research on develo** anticancer agents and based on the proven
proprieties of thieno [2, 3‐b] pyridines as anticancer, we have designed to synthesize novel …

Cyano‐5‐ethoxycarbonyl‐6‐methyl‐4‐(2′‐thienyl)‐pyridine‐2 (1 H)‐thione (1) is
synthesized and reacted with chloroacetamide or chloroacetonitrile to give 3‐amino‐5 …

Due to the implication of adenosine in seizure suppression, adenosine-based therapies
such as adenosine receptor (AR) agonists have been investigated. This study aimed at …

In the past years, many diazenyl compounds (ie diazenecarboxamides, diazeniumdiolate
prodrugs, diazenyl complexes etc.) have been prepared for the evaluation of their cytotoxic …