The functions of animal microRNAs

V Ambros - Nature, 2004 - nature.com
MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary
messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and …

Oncomirs—microRNAs with a role in cancer

A Esquela-Kerscher, FJ Slack - Nature reviews cancer, 2006 - nature.com
MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function
as negative gene regulators. They regulate diverse biological processes, and bioinformatic …

[HTML][HTML] RAS is regulated by the let-7 microRNA family

SM Johnson, H Grosshans, J Shingara, M Byrom… - Cell, 2005 - cell.com
MicroRNAs (miRNAs) are regulatory RNAs found in multicellular eukaryotes, including
humans, where they are implicated in cancer. The let-7 miRNA times seam cell terminal …

A microRNA polycistron as a potential human oncogene

L He, JM Thomson, MT Hemann, E Hernando-Monge… - nature, 2005 - nature.com
To date, more than 200 microRNAs have been described in humans; however, the precise
functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of …

microRNA functions

N Bushati, SM Cohen - Annu. Rev. Cell Dev. Biol., 2007 - annualreviews.org
microRNAs (miRNAs) are small noncoding RNAs that play important roles in
posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by …

[HTML][HTML] miRWalk–database: prediction of possible miRNA binding sites by “walking” the genes of three genomes

H Dweep, C Sticht, P Pandey, N Gretz - Journal of biomedical informatics, 2011 - Elsevier
MicroRNAs are small, non-coding RNA molecules that can complementarily bind to the
mRNA 3′-UTR region to regulate the gene expression by transcriptional repression or …

MicroRNA biogenesis: coordinated crop** and dicing

VN Kim - Nature reviews Molecular cell biology, 2005 - nature.com
The recent discovery of microRNAs (miRNAs) took many by surprise because of their
unorthodox features and widespread functions. These tiny,∼ 22-nucleotide, RNAs control …

The diverse functions of microRNAs in animal development and disease

WP Kloosterman, RHA Plasterk - Developmental cell, 2006 - cell.com
MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization
of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in …

A brain-specific microRNA regulates dendritic spine development

GM Schratt, F Tuebing, EA Nigh, CG Kane, ME Sabatini… - Nature, 2006 - nature.com
MicroRNAs are small, non-coding RNAs that control the translation of target messenger
RNAs, thereby regulating critical aspects of plant and animal development. In the …

The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease

E Mogilyansky, I Rigoutsos - Cell Death & Differentiation, 2013 - nature.com
Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …