Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

M Vallet-Regí, F Schüth, D Lozano, M Colilla… - Chemical Society …, 2022 - pubs.rsc.org
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …

The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials

L Zeng, P Gupta, Y Chen, E Wang, L Ji… - Chemical Society …, 2017 - pubs.rsc.org
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

Mesoporous silica nanoparticles for drug delivery: Current insights

M Vallet-Regí, M Colilla, I Izquierdo-Barba, M Manzano - Molecules, 2017 - mdpi.com
This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug
delivery systems. Their intrinsic structural, textural and chemical features permit to design …

Engineering of a nanosized biocatalyst for combined tumor starvation and low-temperature photothermal therapy

J Zhou, M Li, Y Hou, Z Luo, Q Chen, H Cao, R Huo… - ACS …, 2018 - ACS Publications
Tumor hypoxia is one of the major challenges for the treatment of tumors, as it may
negatively affect the efficacy of various anticancer modalities. In this study, a tumor-targeted …

The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017 - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

Sol–gel‐based advanced porous silica materials for biomedical applications

Q Lei, J Guo, A Noureddine, A Wang… - Advanced Functional …, 2020 - Wiley Online Library
Porous silica‐based materials have burgeoning applications ranging from fillers and
additives, to adsorbents, catalysts, and recently therapeutic agents and vaccines in …

Mechanisms of drug release in nanotherapeutic delivery systems

PT Wong, SK Choi - Chemical reviews, 2015 - ACS Publications
Targeted drug delivery refers to an established therapeutic strategy that develops platforms
and nanoscale devices for selective delivery of small drug molecules and therapeutic genes …

Recent advances in ruthenium (II) and iridium (III) complexes containing nanosystems for cancer treatment and bioimaging

J Shen, TW Rees, L Ji, H Chao - Coordination chemistry reviews, 2021 - Elsevier
Ruthenium (II) and iridium (III) coordination compounds display excellent structural,
photophysical, and biological properties which make them highly promising as anticancer …

[PDF][PDF] An amphiphilic ruthenium polymetallodrug for combined photodynamic therapy and photochemotherapy in vivo

W Sun, S Li, B Häupler, J Liu, S **, W Steffen… - Adv. Mater, 2017 - d-nb.info
The success of several FDA-approved platinum anticancer drugs has stimulated increasing
interest in the development of new metallodrugs.[1] Ruthenium (Ru) complexes are potential …

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery

A Baeza, M Colilla, M Vallet-Regí - Expert opinion on drug delivery, 2015 - Taylor & Francis
Introduction: Mesoporous silica nanoparticles (MSNPs) are one of the most promising
inorganic drug delivery systems (DDSs). The design and development of tumour-targeted …