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Towards clinical translation of FLASH radiotherapy
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
FLASH: New intersection of physics, chemistry, biology, and cancer medicine
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …
innovations over the past decade in the field of radiation oncology, with the potential to …
Tumour irradiation in mice with a laser-accelerated proton beam
Recent oncological studies identified beneficial properties of radiation applied at ultrahigh
dose rates, several orders of magnitude higher than the clinical standard of the order of Gy …
dose rates, several orders of magnitude higher than the clinical standard of the order of Gy …
[HTML][HTML] In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH
Background and purpose Preclinical studies indicate a normal tissue sparing effect using
ultra-high dose rate (FLASH) radiation with comparable tumor response. Most data so far …
ultra-high dose rate (FLASH) radiation with comparable tumor response. Most data so far …
Emerging technologies for cancer therapy using accelerated particles
Cancer therapy with accelerated charged particles is one of the most valuable biomedical
applications of nuclear physics. The technology has vastly evolved in the past 50 years, the …
applications of nuclear physics. The technology has vastly evolved in the past 50 years, the …
[HTML][HTML] Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model
Purpose Preclinical studies indicate a normal tissue sparing effect when ultra-high dose rate
(FLASH) radiation is used, while tumor response is maintained. This differential response …
(FLASH) radiation is used, while tumor response is maintained. This differential response …
Mechanisms of action in FLASH radiotherapy: A comprehensive review of physicochemical and biological processes on cancerous and normal cells
JCL Chow, HE Ruda - Cells, 2024 - mdpi.com
The advent of FLASH radiotherapy (FLASH-RT) has brought forth a paradigm shift in cancer
treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (> …
treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (> …
[HTML][HTML] FLASH radiotherapy and the use of radiation dosimeters
Simple Summary FLASH radiotherapy (RT) delivering ultra-high dose rate radiation can
reduce normal tissue toxicity while effectively treating tumors. However, implementing …
reduce normal tissue toxicity while effectively treating tumors. However, implementing …
[HTML][HTML] Radiobiological aspects of FLASH radiotherapy
Radiotherapy (RT) is one of the primary treatment modalities for cancer patients. The clinical
use of RT requires a balance to be struck between tumor effect and the risk of toxicity …
use of RT requires a balance to be struck between tumor effect and the risk of toxicity …
Flash radiotherapy: Innovative cancer treatment
JCL Chow, HE Ruda - Encyclopedia, 2023 - mdpi.com
Definition Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …