Towards clinical translation of FLASH radiotherapy

MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

FLASH: New intersection of physics, chemistry, biology, and cancer medicine

MC Vozenin, BW Loo Jr, S Tantawi, PG Maxim… - Reviews of Modern …, 2024 - APS
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …

Tumour irradiation in mice with a laser-accelerated proton beam

F Kroll, FE Brack, C Bernert, S Bock, E Bodenstein… - Nature Physics, 2022 - nature.com
Recent oncological studies identified beneficial properties of radiation applied at ultrahigh
dose rates, several orders of magnitude higher than the clinical standard of the order of Gy …

[HTML][HTML] In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH

BS Sørensen, MK Sitarz, C Ankjærgaard… - Radiotherapy and …, 2022 - Elsevier
Background and purpose Preclinical studies indicate a normal tissue sparing effect using
ultra-high dose rate (FLASH) radiation with comparable tumor response. Most data so far …

Emerging technologies for cancer therapy using accelerated particles

C Graeff, L Volz, M Durante - Progress in particle and nuclear physics, 2023 - Elsevier
Cancer therapy with accelerated charged particles is one of the most valuable biomedical
applications of nuclear physics. The technology has vastly evolved in the past 50 years, the …

[HTML][HTML] Pencil beam scanning proton FLASH maintains tumor control while normal tissue damage is reduced in a mouse model

BS Sørensen, MK Sitarz, C Ankjærgaard… - Radiotherapy and …, 2022 - Elsevier
Purpose Preclinical studies indicate a normal tissue sparing effect when ultra-high dose rate
(FLASH) radiation is used, while tumor response is maintained. This differential response …

Mechanisms of action in FLASH radiotherapy: A comprehensive review of physicochemical and biological processes on cancerous and normal cells

JCL Chow, HE Ruda - Cells, 2024 - mdpi.com
The advent of FLASH radiotherapy (FLASH-RT) has brought forth a paradigm shift in cancer
treatment, showcasing remarkable normal cell sparing effects with ultra-high dose rates (> …

[HTML][HTML] FLASH radiotherapy and the use of radiation dosimeters

S Siddique, HE Ruda, JCL Chow - Cancers, 2023 - mdpi.com
Simple Summary FLASH radiotherapy (RT) delivering ultra-high dose rate radiation can
reduce normal tissue toxicity while effectively treating tumors. However, implementing …

[HTML][HTML] Radiobiological aspects of FLASH radiotherapy

E Hageman, PP Che, M Dahele, BJ Slotman, P Sminia - Biomolecules, 2022 - mdpi.com
Radiotherapy (RT) is one of the primary treatment modalities for cancer patients. The clinical
use of RT requires a balance to be struck between tumor effect and the risk of toxicity …

Flash radiotherapy: Innovative cancer treatment

JCL Chow, HE Ruda - Encyclopedia, 2023 - mdpi.com
Definition Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …