During the past two decades, the incidence of invasive fungal infections has been
increasing dramatically. Clinical available antifungal agents have several drawbacks such …

Currently, the available antifungal agents have significant clinical incompetency in terms of
their clinical efficacy, antifungal spectrum, unfavorable pharmacokinetic profiles, substantial …

A series of novel 1, 2, 4-triazole derivatives with a 4-(4-substitutedphenyl) piperazine side
chain were designed and synthesized based on the structure of lanosterol 14α-demethylase …

Synthesis and antifungal activity of hybrids of thiazolo [4, 5-d] pyrimidines with (1H-1, 2, 4)
triazoles are presented. The solubility and lipophilicity of compounds was assessed and it …

Conventional risk assessments for crop protection chemicals compare the potential for
causing toxicity (hazard identification) to anticipated exposure. New regulatory approaches …

Over the past decades, a tremendous rise in invasive fungal infection diseases attributed to
the yeast Candida albicans in immunocompromised individuals poses a seriously …

Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological
properties, which could play a major role in the common mechanisms associated with …

In this study two series of fluconazole derivatives bearing nitrotriazole (series A) or
piperazine ethanol (series B) side chain were designed and synthesized and then docked in …

Abstract A series of 2-(2, 4-difluorophenyl)-2-hydroxy-3-(1H-1, 2, 4-triazol-1-yl) propyl
dithiocarbamates as new analogs of fluconazole were synthesized and their antifungal …

A series of azole-containing piperazine derivatives have been designed and synthesized.
The obtained compounds were investigated in vitro for their antibacterial, antifungal and …