Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence
and soon will be the second leading cause of cancer death in the USA. This is a deadly …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers
with a median survival of 6 months after diagnosis. Intrinsic resistance to chemotherapeutics …

Pancreatic ductal adenocarcinoma is one of the deadliest cancers worldwide and the fourth
leading cause of cancer-related deaths in United States. Regardless of the advances in …

Simple Summary The current obstacles for discovering new drugs for cancer therapy have
necessitated the development of the alternative strategy of drug repurposing, the …

Profiling of whole transcriptomes has become a cornerstone of molecular biology and an
invaluable tool for the characterization of clinical phenotypes and the identification of …

Background Sonic hedgehog (SHH) plays critical roles in cell growth and development.
Tumor cells express SHH, which can promote cell proliferation and epithelial-to …

Super-enhancers (SEs) are unique areas of the genome which drive high-level of
transcription and play a pivotal role in the cell physiology. Previous studies have established …

MiR-200a has been reported to be able to suppress the epithelial-mesenchymal transition
process in pancreatic cancer stem cells, suggesting that miR-200a could suppress the …

Aberrant activation of the Hedgehog (Hh) signalling pathway has been associated with the
development and progression of pancreatic cancer. For this reason, blockade of Hh pathway …

Since the discovery of the Hedgehog (Hh) pathway in drosophila melanogaster, our
knowledge of the role of Hh in embryonic development, inflammation, and cancerogenesis …