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The structural variability of the influenza A hemagglutinin receptor-binding site
M Lazniewski, WK Dawson… - Briefings in …, 2018 - academic.oup.com
Hemagglutinin (HA) is a transmembrane protein of the influenza A virus and a key
component in its life cycle. The protein allows the virus to enter a host cell by recognizing …
component in its life cycle. The protein allows the virus to enter a host cell by recognizing …
Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling
L Unione, ANA Ammerlaan, GP Bosman, E Uslu… - Nature …, 2024 - nature.com
Prototypic receptors for human influenza viruses are N-glycans carrying α2, 6-linked
sialosides. Due to immune pressure, A/H3N2 influenza viruses have emerged with altered …
sialosides. Due to immune pressure, A/H3N2 influenza viruses have emerged with altered …
Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses
F Broszeit, RJ van Beek, L Unione… - Nature …, 2021 - nature.com
During circulation in humans and natural selection to escape antibody recognition for
decades, A/H3N2 influenza viruses emerged with altered receptor specificities. These …
decades, A/H3N2 influenza viruses emerged with altered receptor specificities. These …
N-benzyl 4, 4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction
S de Castro, T Ginex, E Vanderlinden, M Laporte… - European Journal of …, 2020 - Elsevier
The influenza virus hemagglutinin (HA) is an attractive target for antiviral therapy due to its
essential role in mediating virus entry into the host cell. We here report the identification of a …
essential role in mediating virus entry into the host cell. We here report the identification of a …
An integrated approach to the characterization of immune repertoires using aims: An automated immune molecule separator
CT Boughter… - PLOS Computational …, 2023 - journals.plos.org
The adaptive immune system employs an array of receptors designed to respond with high
specificity to pathogens or molecular aberrations faced by the host organism. Binding of …
specificity to pathogens or molecular aberrations faced by the host organism. Binding of …
Grafting Methionine on 1F1 Ab Increases the Broad-Activity on HA Structural-Conserved Residues of H1, H2, and H3 Influenza a Viruses
HT Le, PC Do, L Le - Evolutionary Bioinformatics, 2021 - journals.sagepub.com
A high level of mutation enables the influenza A virus to resist antibiotics previously effective
against the influenza A virus. A portion of the structure of hemagglutinin HA is assumed to be …
against the influenza A virus. A portion of the structure of hemagglutinin HA is assumed to be …
A Numbering Scheme for Influenza A Virus Neuraminidase (NA) Subtypes
TSR Kumar, GW Chen - TANET2019 臺灣網際網路研討會, 2019 - airitilibrary.com
For influenza viruses, the two glycoproteins hemagglutinin (HA) and neuraminidase (NA)
play important roles in receptor binding, membrane fusion and the release of progeny …
play important roles in receptor binding, membrane fusion and the release of progeny …