Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its
own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a …

Bipolar disorder (BD) is a severe and common chronic mental illness characterized by
recurrent mood swings between depression and mania. The biological basis of the disease …

Reactive oxygen species (ROS) have been shown to play a role in the pathophysiology of
depression. Taking into account that experimental chronic unpredictable stress (CUS) …

Objectives The goal of the present study was to investigate the effects of lithium
administration on behavior, oxidative stress parameters and cytokine levels in the periphery …

Experimental and epidemiological studies have shown the close relationship between
stressful events, depression, and cognitive impairment. Folic acid has been reported to …

Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides
(ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and …

Bipolar disorder (BD) is a chronic and debilitating illness characterized by recurrent manic
and depressive episodes. Our research investigates the protective effects of curcumin, the …

Mood disorders are a leading cause of morbidity and mortality, yet their underlying
pathophysiology remains unclear. Animal models serve as a powerful tool for investigating …

A particular challenge in the development of a bipolar disorder (BD) model in animals is the
complicated clinical course of the condition, characterized by manic, depressive and mixed …

The current pathophysiological understanding of mechanisms leading to onset and
progression of bipolar manic episodes remains limited. At the same time, available animal …