Squamous-cell cancer of the head and neck (SCCHN) represents a heterogeneous disease
entity, with various etiological factors implicated in the genesis of distinct molecular subsets …

Context.—Immunohistochemistry has taken a central role in the field of pathology, and its
role is destined to increase as companion diagnostics analogous to the HercepTest are …

Purpose To determine if computed tomographic (CT) texture and histogram analysis
measurements of the primary mass are independently associated with overall survival in …

Background: Several lines of evidence support the epidermal growth factor receptor (EGFR)
as a molecular target for therapy in head and neck squamous cell carcinomas (HNSCC) …

Advances in understanding of the molecular mechanisms underlying oral squamous cell
carcinoma (OSCC) have resulted in an increasing number of biomarkers that can be used to …

Background: Several lines of laboratory evidence support the epidermal growth factor
receptor (EGFR) as an adverse prognostic indicator in ovarian cancers. However, different …

Tissue microarray (TMA) is a recently implemented, high-throughput technology for the
analysis of molecular markers in oncology. This research tool permits the rapid assessment …

Purpose: Cetuximab, an antibody directed against the EGF receptor, is an effective clinical
therapy for patients with head and neck squamous cell cancer (HNSCC). Despite great …

The CCND1 gene encodes the protein CyclinD1, which is an important promoter of the cell
cycle and a prognostic and predictive factor in different cancers. CCND1 is amplified to a …

Abstract Human papillomavirus–related (p16-positive) oropharyngeal squamous cell
carcinoma patients develop recurrent disease, mostly distant metastasis, in approximately …