Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

The pathophysiology of gestational diabetes mellitus

JF Plows, JL Stanley, PN Baker, CM Reynolds… - International journal of …, 2018 - mdpi.com
Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women
without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In …

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

GB Rogers, DJ Keating, RL Young, ML Wong… - Molecular …, 2016 - nature.com
The human body hosts an enormous abundance and diversity of microbes, which perform a
range of essential and beneficial functions. Our appreciation of the importance of these …

Vitamin D for health: a global perspective

A Hossein-nezhad, MF Holick - Mayo clinic proceedings, 2013 - Elsevier
It is now generally accepted that vitamin D deficiency is a worldwide health problem that
affects not only musculoskeletal health but also a wide range of acute and chronic diseases …

Epigenetic responses and the developmental origins of health and disease

D Goyal, SW Limesand, R Goyal - Journal of Endocrinology, 2019 - joe.bioscientifica.com
Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …

Prenatal stress and its effects on the fetus and the child: possible underlying biological mechanisms

V Glover - Perinatal programming of neurodevelopment, 2015 - Springer
Many prospective studies have shown that if a mother is depressed, anxious or stressed
while pregnant, this increases the risk for her child having a wide range of adverse …

The immune system and developmental programming of brain and behavior

SD Bilbo, JM Schwarz - Frontiers in neuroendocrinology, 2012 - Elsevier
The brain, endocrine, and immune systems are inextricably linked. Immune molecules have
a powerful impact on neuroendocrine function, including hormone–behavior interactions …

Transfer of maternal psychosocial stress to the fetus

F Rakers, S Rupprecht, M Dreiling, C Bergmeier… - Neuroscience & …, 2020 - Elsevier
Psychosocial maternal stress experienced during different vulnerable periods throughout
gestation is thought to increase the individual's risk to develop neuropsychiatric …

The placenta in fetal growth restriction: what is going wrong?

C Sun, KM Groom, C Oyston, LW Chamley, AR Clark… - Placenta, 2020 - Elsevier
The placenta is essential for the efficient delivery of nutrients and oxygen from mother to
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …

The developmental origins of chronic disease

DJP Barker - Families and child health, 2013 - Springer
The search for the causes of chronic adult diseases and the way to prevent them has largely
failed. For example, there are now 350 million people around the world who have type 2 …