Cryo-electron microscopy (cryo-EM) has emerged as an unprecedented tool to resolve
protein structures at atomic resolution. Structural insights of biological samples not …

RNA molecules adopt three-dimensional structures that are critical to their function and of
interest in drug discovery. Few RNA structures are known, however, and predicting them …

RNAs play critical roles in most biological processes. Although the three-dimensional (3D)
structures of RNAs primarily determine their functions, it remains challenging to …

Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA
genome. The highly conserved frameshift stimulation element (FSE), required for balanced …

DNA and RNA play fundamental roles in various cellular processes, where their three-
dimensional structures provide information critical to understanding the molecular …

The discovery and design of biologically important RNA molecules is outpacing three-
dimensional structural characterization. Here, we demonstrate that cryo-electron microscopy …

The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding
RNA (lncRNA) has key roles in regulating transcription, splicing, tumorigenesis, etc. Its …

T-box riboswitches are multi-domain noncoding RNAs that surveil individual amino acid
availabilities in most Gram-positive bacteria. T-boxes directly bind specific tRNAs, query …

Protein kinase Gcn2 attenuates protein synthesis in response to amino acid starvation while
stimulating translation of a transcriptional activator of amino acid biosynthesis. Gcn2 …

High-resolution structural studies are essential for understanding the folding and function of
diverse RNAs. Herein, we present a nanoarchitectural engineering strategy for efficient …