[HTML][HTML] Obesity-induced asthma: role of free fatty acid receptors

K Mizuta, A Matoba, S Shibata, E Masaki… - … Dental Science Review, 2019 - Elsevier
Obesity is a major risk factor for the development of asthma, and worsens the key features of
asthma including airway hyperresponsiveness, inflammation, and airway remodeling …

The many faces of asthma in obesity

O Sideleva, AE Dixon - Journal of cellular biochemistry, 2014 - Wiley Online Library
Obesity is a major risk factor for the development of asthma, and causes severe,
uncontrolled disease that responds poorly to therapy. The obese state alters early onset …

The free fatty acid receptor 1 promotes airway smooth muscle cell proliferation through MEK/ERK and PI3K/Akt signaling pathways

A Matoba, N Matsuyama, S Shibata… - … of Physiology-Lung …, 2018 - journals.physiology.org
Obesity is a risk factor for asthma and influences airway hyperresponsiveness, which is in
part modulated by airway smooth muscle proliferative remodeling. Plasma free fatty acids …

Obesity increases eosinophil activity in asthmatic children and adolescents

MB Grotta, DM Squebola-Cola, AADC Toro… - BMC pulmonary …, 2013 - Springer
Background A clear relationship between asthma and obesity has been reported, but the
mechanisms remain unclear. The aim of this study was to evaluate the influence of obesity …

Influence of distinct asthma phenotypes on lung function following weight loss in the obese

DG Chapman, CG Irvin, DA Kaminsky… - …, 2014 - Wiley Online Library
Background and objective There appears to be two distinct clinical phenotypes of obese
patients with asthma—those with early‐onset asthma and high serum IgE (TH2‐high), and …

[HTML][HTML] Role of obesity in inflammation and remodeling of asthmatic airway

H Shailesh, IA Janahi - Life, 2022 - mdpi.com
Obesity is considered as an important risk factor for the onset of asthma and plays a key role
in enhancing the disease's severity. Obese asthmatic individuals represent a distinct …

Impact of abdominal visceral adiposity on adult asthma symptoms

H Goudarzi, S Konno, H Kimura, H Makita… - The Journal of Allergy …, 2019 - Elsevier
Background Previous studies have shown the association of anthropometric measures with
poor asthma symptoms, especially among women. However, the potential influence of …

Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease

MD Ihrie, VL McQuade, JT Womble, A Hegde… - Respiratory …, 2022 - Springer
Background Asthma patients with comorbid obesity exhibit increased disease severity, in
part, due to airway remodeling, which is also observed in mouse models of asthma and …

Treatment of obese asthma in a mouse model by simvastatin is associated with improving dyslipidemia and decreasing leptin level

W Han, J Li, H Tang, L Sun - Biochemical and biophysical research …, 2017 - Elsevier
Obesity can cause or worsen asthma. Compared with common asthma, obese asthma is
difficult to control. Statins are effective serum cholesterol-lowering agents in clinical practice …

High-fat diet promotes lung fibrosis and attenuates airway eosinophilia after exposure to cockroach allergen in mice

XN Ge, Y Greenberg, MR Hosseinkhani… - Experimental lung …, 2013 - Taylor & Francis
Obesity is an important risk factor for asthma but the mechanistic basis for this association is
not well understood. In the current study, the impact of obesity on lung inflammatory …