Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Immune checkpoint blockade (ICB) can produce durable responses against cancer. We and
others have found that a subset of patients experiences paradoxical rapid cancer …

Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting
step of glycolysis is the conversion of Phosphoenolpyruvate (PEP) to Pyruvate, which is …

Glucose metabolism is known to orchestrate oncogenesis. Whether glucose serves as a
signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive …

Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …

Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes
and tumor suppressors, leading to the constitutive activation of signaling pathways involved …

Cancer is driven by genetic and epigenetic alterations that allow cells to overproliferate and
escape mechanisms that normally control their survival and migration. Many of these …

Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their
metabolic activity. We here show that LPS induces expression of the key metabolic regulator …