Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …

Long considered both physiologic and inevitable, skin aging is a degenerative phenomenon
whereby both intrinsic and environmental factors conspire to produce an authentic disease …

Ageing is influenced by the intrinsic disposition delineating what is maximally possible and
extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic …

The growing concern over appearance, health and aging has driven the exploration for
cosmetics based on natural sources. Alongside with plants, algae and eukaryotic …

Most molecular hallmarks of cellular senescence have been identified in studies of cells
aged in vitro by driving them into replicative or stress-induced senescence. Comparatively …

Aging is a natural process in humans as accumulation of oxygen-derived free radicals which
leads to the activation of hyaluronidase, collagenase and elastase, that can further …

Background The large unmet need of hidradenitis suppurativa/acne inversa (HS) therapy
requires the elucidation of disease‐driving mechanisms and tissue targeting. Objective …

Background Tauopathies are a group of age-related neurodegenerative diseases
characterized by the accumulation of pathologically hyperphosphorylated tau protein in the …

Although senescence was originally described as an in vitro acquired cellular characteristic,
it was recently recognized that senescence is physiologically and pathologically involved in …