Recent studies of nitrogen and sulfur containing heterocyclic analogues as novel antidiabetic agents: a review
S Gharge, SG Alegaon - Chemistry & Biodiversity, 2024 - Wiley Online Library
The prevalence of diabetes mellitus is on the rise, which demands the identification of novel
antidiabetic drugs. There is a need for safer and more effective alternatives because the …
antidiabetic drugs. There is a need for safer and more effective alternatives because the …
[HTML][HTML] Synthesis, biological evaluation and molecular docking study of pyrimidine based thiazolidinone derivatives as potential anti-urease and anti-cancer agents
Hybrid analogs containing molecules are always the choice of different synthetic researcher
due to their diverse biological applications and significantly more efficient. Heterocyclic …
due to their diverse biological applications and significantly more efficient. Heterocyclic …
Benzimidazole-based schiff base hybrid scaffolds: a promising approach to develop multi-target drugs for alzheimer's disease
A series of benzimidazole-based Schiff base derivatives (1–18) were synthesized and
structurally elucidated through 1H NMR, 13C NMR and HREI-MS analysis. Subsequently …
structurally elucidated through 1H NMR, 13C NMR and HREI-MS analysis. Subsequently …
[HTML][HTML] Bis-indole based triazine derivatives: Synthesis, characterization, in vitro β-glucuronidase anti-cancer and anti-bacterial evaluation along with in silico …
The present work described the synthetic procedure adopted for the synthesis of bis-indole-
based triazine derivatives via a series of reactions. All the compounds were synthesized …
based triazine derivatives via a series of reactions. All the compounds were synthesized …
[HTML][HTML] Identification of novel oxadiazole-based benzothiazole derivatives as potent inhibitors of α-glucosidase and urease: synthesis, in vitro bio-evaluation and their …
This research work represents a synthetic approach for the development of hybrids
derivatives of oxadiazole-based benzothiazole (1–17) and diversity in derivatives was …
derivatives of oxadiazole-based benzothiazole (1–17) and diversity in derivatives was …
[HTML][HTML] Investigation of novel bis-thiadiazole bearing schiff base derivatives as effective inhibitors of thymidine phosphorylase: Synthesis, in vitro bioactivity and …
Thymidine phosphorylase (TP) is an angiogenic enzyme. It is crucial for the development,
invasion and metastasis of tumors as well as angiogenesis. In our current research, we …
invasion and metastasis of tumors as well as angiogenesis. In our current research, we …
Hybrid molecules of thiadiazole-based benzothioate and benzenesulfonothioate: synthesis, structural analysis, and evaluation as potential inhibitors of thymidine …
The thiadiazole-based benzothioate (3a-f) and benzenesulfonothioate (5a-f) hybrid
derivatives were designed and synthesized in a single step reaction. All the synthesized …
derivatives were designed and synthesized in a single step reaction. All the synthesized …
Antidiabetic potential of novel 1, 3, 5-trisubstituted-2-thioxoimidazloidin-4-one analogues: Insights into α-glucosidase, α-amylase, and antioxidant activities
As the ninth leading cause of death globally, diabetes mellitus (DM) is considered to be the
worst chronic metabolic disease requiring an enormous need for healthcare with over 578 …
worst chronic metabolic disease requiring an enormous need for healthcare with over 578 …
Hybrid benzothiazole derived fused triazole/thiazole derivatives as versatile anti-Alzheimer agents: synthesis, characterization, biological evaluation and molecular …
Alzheimer's disease, as per reports, 50 million people worldwide suffer from dementia and
an increase of 152 million is expected by 2050. This study reports a novel synthetic …
an increase of 152 million is expected by 2050. This study reports a novel synthetic …
[HTML][HTML] Experimental and computational pharmacological approaches decoding the anti-diabetic molecular mechanism of indole based triazole bearing …
In search for a potent anti-Diabetes therapeutic agent, we have synthesized a series of
indole based triazole derived sulfonothioate derivatives (1–15). These compounds were …
indole based triazole derived sulfonothioate derivatives (1–15). These compounds were …