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Inhibition of bacterial RNA polymerase function and protein–protein interactions: a promising approach for next-generation antibacterial therapeutics
The increasing prevalence of multidrug-resistant pathogens necessitates the urgent
development of new antimicrobial agents with innovative modes of action for the next …
development of new antimicrobial agents with innovative modes of action for the next …
Development of a luciferase-based Gram-positive bacterial reporter system for the characterization of antimicrobial agents
NM Lam, TF Tsang, J Qu, MW Tsang… - Applied and …, 2024 - journals.asm.org
Mechanistic investigations are of paramount importance in elucidating the modes of action
of antibiotics and facilitating the discovery of novel drugs. We reported a luciferase-based …
of antibiotics and facilitating the discovery of novel drugs. We reported a luciferase-based …
Discovery of Inhibitors Targeting Protein–Protein Interaction between Bacterial RNA Polymerase and NusG as Novel Antimicrobials
Y Zheng, CH Kan, TF Tsang, Y Liu, T Liu… - Journal of Medicinal …, 2024 - ACS Publications
Bacterial RNA polymerase (RNAP), the core enzyme responsible for bacterial transcription,
requires the NusG factor for efficient transcription elongation and termination. As the primary …
requires the NusG factor for efficient transcription elongation and termination. As the primary …
Discovery of natural products as influenza neuraminidase inhibitors: in silico screening, in vitro validation, and molecular dynamic simulation studies
B Huang, B Lin, H Zheng, B Zheng, X Xue, M Liu - Molecular Diversity, 2025 - Springer
Influenza is a highly contagious respiratory illness that imposes a significant global burden.
Antiviral neuraminidase inhibitors (NAIs) such as oseltamivir (OC) have been proven …
Antiviral neuraminidase inhibitors (NAIs) such as oseltamivir (OC) have been proven …