Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) has been
tested in advanced melanoma patients at various centers. We conducted a systematic …

In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …

Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive
description of its genomic landscape is lacking,,,,,,–. Here we perform whole-genome …

Immune checkpoint inhibitors (ICIs) have substantially improved the survival of cancer
patients over the past several years. However, only a minority of patients respond to ICI …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …

Mismatch repair (MMR)-deficient cancer evolves through the stepwise erosion of coding
homopolymers in target genes. Curiously, the MMR genes MutS homolog 6 (MSH6) and …

The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly
understood due to limited samples or targeted genes in current studies. Here, we perform …

Studies have characterized the immune escape landscape across primary tumors. However,
whether late-stage metastatic tumors present differences in genetic immune escape (GIE) …

Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …

T cell-mediated immune therapies have emerged as a promising treatment modality in
different malignancies including colorectal cancer (CRC). However, only a fraction of …