Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …

Structural and functional variability of human leukocyte antigen (HLA) is the foundation for
competent adaptive immune responses against pathogen and tumor antigens as it assures …

The current rate of species extinction is rapidly approaching unprecedented highs, and life
on Earth presently faces a sixth mass extinction event driven by anthropogenic activity …

We report detailed peptide‐binding affinities between 438 HLA Class I and Class II proteins
and complete proteomes of seven pandemic human viruses, including coronaviruses …

The role of natural selection in the evolution of trait complexity can be characterized by
testing hypothesized links between complex forms and their functions across species …

Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance,
suggesting that their immune system might have evolved to facilitate these phenotypes …

The immeasurable complexity at every level of biological organization creates a daunting
task for understanding biological function. Here, we highlight the risks of strip** it away at …

Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …

Background The host immune response has a prominent role in the progression and
outcome of SARS-CoV-2 infection. Lymphopenia has been described as an important …

A comprehensive knowledge of human leukocyte antigen (HLA) molecular variation
worldwide is essential in human population genetics research and disease association …