Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

Four grams of glucose circulates in the blood of a person weighing 70 kg. This glucose is
critical for normal function in many cell types. In accordance with the importance of these 4 g …

Defects in liver and muscle glycogen synthesis are major factors contributing to
postprandrial hyperglycemia in patients with type 2 diabetes. Therefore, activation of …

Skeletal muscle glucose uptake increases dramatically in response to physical exercise.
Moreover, skeletal muscle comprises the vast majority of insulin-sensitive tissue and is a site …

At least eight distinct pathophysiologic abnormalities have been associated with type 2
diabetes mellitus (T2DM). It is well established that decreased peripheral glucose uptake …

Research conducted over the last 50 yr has provided insight into the mechanisms by which
insulin stimulates glucose transport across the skeletal muscle cell membrane Transport …

After an overnight fast (postabsorptive state), the majority of total body glucose utilization
takes place in insulin-dependent tissues. 1 Under basal conditions, approximately 50% of all …

Aims/hypothesis Human brown adipose tissue (BAT) has recently emerged as a potential
target in the treatment of type 2 diabetes, owing to its capacity to actively clear glucose from …