Enterovirus A71: virulence, antigenicity, and genetic evolution over the years
SW Huang, D Cheng, JR Wang - Journal of Biomedical Science, 2019 - Springer
As a neurotropic virus, enterovirus A71 (EV-A71) emerge and remerge in the Asia-Pacific
region since the 1990s, and has continuously been a threat to global public health …
region since the 1990s, and has continuously been a threat to global public health …
Changes in the EV-A71 genome through recombination and spontaneous mutations: impact on virulence
MB Mandary, CL Poh - Viruses, 2018 - mdpi.com
Enterovirus 71 (EV-A71) is a major etiological agent of hand, foot and mouth disease
(HFMD) that mainly affects young children less than five years old. The onset of severe …
(HFMD) that mainly affects young children less than five years old. The onset of severe …
Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction
Some strains of enterovirus 71 (EV71), but not others, infect leukocytes by binding to a
specific receptor molecule: the P-selectin glycoprotein ligand-1 (PSGL-1). We find that a …
specific receptor molecule: the P-selectin glycoprotein ligand-1 (PSGL-1). We find that a …
A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism
Enterovirus 71 (EV71) causes hand, foot and mouth disease, a mild and self-limited illness
that is sometimes associated with severe neurological complications. EV71 neurotropic …
that is sometimes associated with severe neurological complications. EV71 neurotropic …
VP1 amino acid residue 145 of enterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody during cynomolgus monkey infection
K Fujii, Y Sudaka, A Takashino, K Kobayashi… - Journal of …, 2018 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease
and sometimes causes severe or fatal neurological complications. The amino acid at VP1 …
and sometimes causes severe or fatal neurological complications. The amino acid at VP1 …
Characterization of coxsackievirus A6-and enterovirus 71-associated hand foot and mouth disease in Bei**g, China, from 2013 to 2015
J Li, Y Sun, Y Du, Y Yan, D Huo, Y Liu, X Peng… - Frontiers in …, 2016 - frontiersin.org
Background: Etiology surveillance of Hand Foot and Mouth disease (HFMD) in Bei**g
showed that Coxsackievirus A6 (CVA6) became the major pathogen of HFMD in 2013 and …
showed that Coxsackievirus A6 (CVA6) became the major pathogen of HFMD in 2013 and …
Characterization of severe hand, foot, and mouth disease in Shenzhen, China, 2009–2013
Y Huang, Y Zhou, H Lu, H Yang, Q Feng… - Journal of medical …, 2015 - Wiley Online Library
Hand, foot, and mouth disease (HFMD) is caused by human enteroviruses, especially by
enterovirus 71 (EV71) and coxsackievirus A16 (CA16). Patients infected with different …
enterovirus 71 (EV71) and coxsackievirus A16 (CA16). Patients infected with different …
Amino acid variation at VP1-145 of enterovirus A71 determines the viral infectivity and receptor usage in a primary human intestinal model
I Aknouch, I García-Rodríguez, FP Giugliano… - Frontiers in …, 2023 - frontiersin.org
Enterovirus A71 (EV-A71) can elicit a wide variety of human diseases such as hand, foot,
and mouth disease and severe or fatal neurological complications. It is not clearly …
and mouth disease and severe or fatal neurological complications. It is not clearly …
The role of VP1 amino acid residue 145 of enterovirus 71 in viral fitness and pathogenesis in a cynomolgus monkey model
C Kataoka, T Suzuki, O Kotani… - PLoS …, 2015 - journals.plos.org
Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease,
occasionally causes severe neurological symptoms. We identified P-selectin glycoprotein …
occasionally causes severe neurological symptoms. We identified P-selectin glycoprotein …
Amino acid variation at VP1-145 of enterovirus 71 determines attachment receptor usage and neurovirulence in human scavenger receptor B2 transgenic mice
K Kobayashi, Y Sudaka, A Takashino, A Imura… - Journal of …, 2018 - Am Soc Microbiol
ABSTRACT Infection by enterovirus 71 (EV71) is affected by cell surface receptors, including
the human scavenger receptor B2 (hSCARB2), which are required for viral uncoating, and …
the human scavenger receptor B2 (hSCARB2), which are required for viral uncoating, and …