Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Tissues consist of cells and their surrounding extracellular matrix (ECM). Cell–ECM
interactions play crucial roles in embryonic development, differentiation, tissue remodeling …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …

Simple Summary YAP/TAZ are the central effectors of the Hippo pathway and orchestrate
their oncogenic program by binding to TEAD transcriptional factors. Here, we document a …

Re-activating quiescent adult epicardium represents a potential therapeutic approach for
human cardiac regeneration. However, the exact molecular differences between inactive …

Cardiac fibroblasts play an essential role in the development of the heart and are implicated
in disease progression in the context of fibrosis and regeneration. Here, we establish a …

Force-sensing biophysical cues in microenvironment, including extracellular matrix
performances, stretch-mediated mechanics, shear stress and flow-induced hemodynamics …

RhoA (ras homolog family member A) is a small G-protein that transduces intracellular
signaling to regulate a broad range of cellular functions such as cell growth, proliferation …

Cardiac fibrosis is a common pathological change in the development of heart disease.
Circular RNA (circRNA) has been shown to be related to the occurrence and development of …

Due to aging populations and changes in lifestyle, cardiovascular diseases including
cardiomyopathy, hypertension, and atherosclerosis, are the leading causes of death …