Piper species are aromatic plants used as spices in the kitchen, but their secondary
metabolites have also shown biological effects on human health. These plants are rich in …

Background: Chagas disease (American Trypanosomiasis) is classified by the World Health
Organization (WHO) as one of the seventeen neglected tropical diseases (NTD), affecting …

The term neglected diseases refers to a group of infections caused by various classes of
pathogens, including protozoa, viruses, bacteria, and helminths, most often affecting …

Secondary metabolites obtained from natural sources are medicinally relevant molecules.
About one-third of all FDA-approved drugs are derived from or based on natural products …

This work describes the isolation of six metabolites from leaves and branches of Piper
cernuum (Piperaceae):(−)-cubebin (1),(−)-hinokinin (2),(−)-kusunokinin (3), trans …

X-linked inhibitor of apoptosis protein (XIAP) is an emerging crucial therapeutic target in
cancer. We report on the discovery and characterisation of small organic molecules from …

The problems with current strategies to control canine visceral Leishmaniasis (CVL), which
include the euthanasia of infected animals, and also the toxicity of the drugs currently used …

Alkylphenols isolated from Piper malacophyllum (Piperaceae), gibbilimbols A and B,
showed interesting activity against the parasites Trypanosoma cruzi and Leishmania …

Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without
efficient treatment for chronic patients. Despite the efforts, no new drugs have been …

Background: Neglected tropical diseases are a group of infections caused by
microorganisms and viruses that affect mainly poor regions of the world. In addition, most …