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[HTML][HTML] Peptide therapeutics from venom: Current status and potential
Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …
Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads
Voltage-gated sodium (NaV) channels play a central role in the propagation of action
potentials in excitable cells in both humans and insects. Many venomous animals have …
potentials in excitable cells in both humans and insects. Many venomous animals have …
Deconstructing voltage sensor function and pharmacology in sodium channels
Voltage-activated sodium (Nav) channels are crucial for the generation and propagation of
nerve impulses, and as such are widely targeted by toxins and drugs. The four voltage …
nerve impulses, and as such are widely targeted by toxins and drugs. The four voltage …
The roles of sodium channels in nociception: implications for mechanisms of neuropathic pain
M Liu, JN Wood - Pain medicine, 2011 - academic.oup.com
Animal models have provided useful insights into the development and treatment of
neuropathic pain. New genetic data from both human studies and transgenic mouse models …
neuropathic pain. New genetic data from both human studies and transgenic mouse models …
Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli
Disulfide-rich peptides are the dominant component of most animal venoms. These peptides
have received much attention as leads for the development of novel therapeutic agents and …
have received much attention as leads for the development of novel therapeutic agents and …
Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models
S Yang, Y ** the domain ii voltage sensor in the closed configuration
Peptide toxins with high affinity, divergent pharmacological functions, and isoform-specific
selectivity are powerful tools for investigating the structure-function relationships of voltage …
selectivity are powerful tools for investigating the structure-function relationships of voltage …
Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel
JK Murray, J Ligutti, D Liu, A Zou, L Poppe… - Journal of medicinal …, 2015 - ACS Publications
NaV1. 7 is a voltage-gated sodium ion channel implicated by human genetic evidence as a
therapeutic target for the treatment of pain. Screening fractionated venom from the tarantula …
therapeutic target for the treatment of pain. Screening fractionated venom from the tarantula …