The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …
schizophrenia, affect a significant percentage of the world population. These disorders are …
Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation
D Brites, A Fernandes - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Patients with chronic inflammation are often associated with the emergence of depression
symptoms, while diagnosed depressed patients show increased levels of circulating …
symptoms, while diagnosed depressed patients show increased levels of circulating …
The S100B story: from biomarker to active factor in neural injury
F Michetti, N D'Ambrosi, A Toesca… - Journal of …, 2019 - Wiley Online Library
S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …
Pathogenesis of depression: insights from human and rodent studies
Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …
Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in …
Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …
translatable models for studying the neurobiological basis of major depression. Although the …
Neuroimmune mechanisms of depression
Current diagnosis of depression is based solely on behavioral symptomatology. The
available US Food and Drug Administration–approved treatments for depression have come …
available US Food and Drug Administration–approved treatments for depression have come …
Neuropathology of stress
Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …
increasingly present in our modern, and demanding, industrialized society. Virtually every …
Probiotic gut effect prevents the chronic psychological stress‐induced brain activity abnormality in mice
Background A probiotic formulation (L actobacillus helveticus R0052 and B ifidobacterium
longum R0175 combination, Probio'Stick®) displays anxiolytic‐like activity and reduces …
longum R0175 combination, Probio'Stick®) displays anxiolytic‐like activity and reduces …
Adult neurogenesis, glia, and the extracellular matrix
EC Cope, E Gould - Cell Stem Cell, 2019 - cell.com
In the adult mammalian hippocampus, new neurons arise from stem and progenitor cell
division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive …
division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive …
Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators
MV Sofroniew - The Neuroscientist, 2014 - journals.sagepub.com
Astrocytes are increasingly recognized as exerting complex functions essential for normal
neural activity in the healthy central nervous system (CNS). Because astrocytes also …
neural activity in the healthy central nervous system (CNS). Because astrocytes also …