Scalable production of extracellular vesicles and its therapeutic values: a review
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …
secreted by cells for intercellular communication. Recently, EVs have received much …
Emergence of the stem cell secretome in regenerative engineering
The secretome is defined as the set of molecules and biological factors that are secreted by
cells into the extracellular space. In the past decade, secretome-based therapies have …
cells into the extracellular space. In the past decade, secretome-based therapies have …
Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo
L Bouchareychas, P Duong, S Covarrubias, E Alsop… - Cell reports, 2020 - cell.com
Develo** strategies that promote the resolution of vascular inflammation and
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …
Engineered mesenchymal stromal cell exosomes-loaded microneedles improve corneal healing after chemical injury
F Yu, X Zhao, Q Wang, PH Fang, L Liu, X Du, W Li… - ACS …, 2024 - ACS Publications
Corneal alkali burns represent a prevalent ophthalmic emergency with the potential to
induce blindness. The main contributing mechanisms include excessive inflammation and …
induce blindness. The main contributing mechanisms include excessive inflammation and …
[HTML][HTML] Therapeutic potential of exosome‐based personalized delivery platform in chronic inflammatory diseases
C Wang, M Xu, Q Fan, C Li, X Zhou - Asian journal of pharmaceutical …, 2023 - Elsevier
In the inflammatory microenvironment, there are numerous exosomes secreted by immune
cells (Macrophages, neutrophils, dendritic cells), mesenchymal stem cells (MSCs) and …
cells (Macrophages, neutrophils, dendritic cells), mesenchymal stem cells (MSCs) and …
Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells
Y Tian, F Zhang, Y Qiu, S Wang, F Li, J Zhao… - Nature biomedical …, 2021 - nature.com
Choroidal neovascularization induced by age-related macular degeneration and retinal
neovascularization induced by diabetic retinopathy—two leading causes of blindness—are …
neovascularization induced by diabetic retinopathy—two leading causes of blindness—are …
Prospective therapeutic applications of platelet extracellular vesicles
J Johnson, YW Wu, C Blyth, G Lichtfuss… - Trends in …, 2021 - cell.com
There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for
regenerative medicine and drug delivery. Blood-borne platelets represent a source of …
regenerative medicine and drug delivery. Blood-borne platelets represent a source of …
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
[HTML][HTML] Advances in extracellular vesicle functionalization strategies for tissue regeneration
Extracellular vesicles (EVs) are nano-scale vesicles derived by cell secretion with unique
advantages such as promoting cell proliferation, anti-inflammation, promoting blood vessels …
advantages such as promoting cell proliferation, anti-inflammation, promoting blood vessels …
Overview and update on methods for cargo loading into extracellular vesicles
The enormous library of pharmaceutical compounds presents endless research avenues.
However, several factors limit the therapeutic potential of these drugs, such as drug …
However, several factors limit the therapeutic potential of these drugs, such as drug …