Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

Emergence of the stem cell secretome in regenerative engineering

L Daneshmandi, S Shah, T Jafari, M Bhattacharjee… - Trends in …, 2020 - cell.com
The secretome is defined as the set of molecules and biological factors that are secreted by
cells into the extracellular space. In the past decade, secretome-based therapies have …

Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo

L Bouchareychas, P Duong, S Covarrubias, E Alsop… - Cell reports, 2020 - cell.com
Develo** strategies that promote the resolution of vascular inflammation and
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …

Engineered mesenchymal stromal cell exosomes-loaded microneedles improve corneal healing after chemical injury

F Yu, X Zhao, Q Wang, PH Fang, L Liu, X Du, W Li… - ACS …, 2024 - ACS Publications
Corneal alkali burns represent a prevalent ophthalmic emergency with the potential to
induce blindness. The main contributing mechanisms include excessive inflammation and …

[HTML][HTML] Therapeutic potential of exosome‐based personalized delivery platform in chronic inflammatory diseases

C Wang, M Xu, Q Fan, C Li, X Zhou - Asian journal of pharmaceutical …, 2023 - Elsevier
In the inflammatory microenvironment, there are numerous exosomes secreted by immune
cells (Macrophages, neutrophils, dendritic cells), mesenchymal stem cells (MSCs) and …

Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells

Y Tian, F Zhang, Y Qiu, S Wang, F Li, J Zhao… - Nature biomedical …, 2021 - nature.com
Choroidal neovascularization induced by age-related macular degeneration and retinal
neovascularization induced by diabetic retinopathy—two leading causes of blindness—are …

Prospective therapeutic applications of platelet extracellular vesicles

J Johnson, YW Wu, C Blyth, G Lichtfuss… - Trends in …, 2021 - cell.com
There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for
regenerative medicine and drug delivery. Blood-borne platelets represent a source of …

Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery

T Burnouf, ML Chou, DJ Lundy, EY Chuang… - Journal of Biomedical …, 2023 - Springer
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

[HTML][HTML] Advances in extracellular vesicle functionalization strategies for tissue regeneration

D Zheng, H Ruan, W Chen, Y Zhang, W Cui, H Chen… - Bioactive Materials, 2023 - Elsevier
Extracellular vesicles (EVs) are nano-scale vesicles derived by cell secretion with unique
advantages such as promoting cell proliferation, anti-inflammation, promoting blood vessels …

Overview and update on methods for cargo loading into extracellular vesicles

Y Han, TW Jones, S Dutta, Y Zhu, X Wang… - Processes, 2021 - mdpi.com
The enormous library of pharmaceutical compounds presents endless research avenues.
However, several factors limit the therapeutic potential of these drugs, such as drug …