Psychedelic therapy has witnessed a resurgence in interest in the last decade from the
scientific and medical communities with evidence now building for its safety and efficacy in …

Modern psychedelic research and clinical development is at a crucial inflection point, with
great potential for the treatment of many mental illnesses demonstrated but significant …

Recent controversies have arisen regarding claims of uncritical positive regard and hype
surrounding psychedelic drugs and their therapeutic potential. Criticisms have included that …

Background Psilocybin therapy (PT) produces rapid and persistent antidepressant effects in
major depressive disorder (MDD). However, the long-term effects of PT have never been …

Background Psilocybin therapy is receiving attention as a mental health intervention with
transdiagnostic potential. In line with psychotherapeutic research, qualitative research has …

Objective: The primary aim of this qualitative study was to delineate psychological
mechanisms of change in the first randomized controlled trial of psilocybin-assisted …

Effective interventions for neuropsychiatric disorders may work by rebalancing the brain's
functional hierarchical organization. Here we directly investigated the effects of two different …

Clinical and neuroscientific evidence indicates that transdiagnostic processes contribute to
the generation and maintenance of psychopathological symptoms and disorders. Rigidity …

Every day, hundreds of thousands of people undergo general anesthesia. One hypothesis is
that anesthesia disrupts dynamic stability—the ability of the brain to balance excitability with …

Following decades of prohibition, psychedelic drugs are returning to mainstream psychiatry
and neuroscience. When paired with psychotherapy and administered in a supportive …