Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

The roles of extracellular vesicles in the immune system

EI Buzas - Nature Reviews Immunology, 2023 - nature.com
The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

Challenges and directions in studying cell–cell communication by extracellular vesicles

G van Niel, DRF Carter, A Clayton… - … reviews Molecular cell …, 2022 - nature.com
Extracellular vesicles (EVs) are increasingly recognized as important mediators of
intercellular communication. They have important roles in numerous physiological and …

Therapeutically harnessing extracellular vesicles

L Cheng, AF Hill - Nature reviews Drug discovery, 2022 - nature.com
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

Comprehensive isolation of extracellular vesicles and nanoparticles

Q Zhang, DK Jeppesen, JN Higginbotham… - Nature protocols, 2023 - nature.com
There is an increasing appreciation for the heterogeneous nature of extracellular vesicles
(EVs). In addition, two nonvesicular extracellular nanoparticles (NVEPs), exomeres and …

Extracellular vesicle analysis

A Hendrix, L Lippens, C Pinheiro, C Théry… - Nature Reviews …, 2023 - nature.com
Cells release small, phospholipid membrane-enclosed particles, collectively referred to as
extracellular vesicles (EVs), into their surroundings to enable intercellular communication …

Tumour extracellular vesicles and particles induce liver metabolic dysfunction

G Wang, J Li, L Bojmar, H Chen, Z Li, GC Tobias, M Hu… - Nature, 2023 - nature.com
Cancer alters the function of multiple organs beyond those targeted by metastasis,. Here we
show that inflammation, fatty liver and dysregulated metabolism are hallmarks of …