Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Microcins are low-molecular-weight, ribosomally produced, highly stable, bacterial-inhibitory
molecules involved in competitive, and amensalistic interactions between …

Bacteria use various strategies to compete in an ecological niche, including the production
of bacteriocins. Bacteriocins are ribosomally synthesized antibacterial peptides, and it has …

Natural products remain a critical source of medicines and drug leads. One of the most
rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and …

Genetic information is translated into proteins by the ribosome. Structural studies of the
ribosome and of its complexes with factors and inhibitors have provided invaluable …

An overuse of antibiotics both in human and animal health and as growth promoters in
farming practices has increased the prevalence of antibiotic resistance in bacteria. Antibiotic …

Microviridins and other ω-ester-linked peptides, collectively known as graspetides, are
characterized by side-chain–side-chain linkages installed by ATP-grasp enzymes. Here we …

The ribosome is one of the major targets in the cell for clinically used antibiotics. However,
the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our …

Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …

Antibiotic metabolites and antimicrobial peptides mediate competition between bacterial
species. Many of them hijack inner and outer membrane proteins to enter cells. Sensitivity of …