Duchenne muscular dystrophy is an X-linked disease caused by the absence of functional
dystrophin in the muscle cells. Major advances have led to the development of gene …

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused
by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly …

The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Skeletal muscle tissue provides mechanical force for locomotion of all vertebrate animals. It
is prone to damage from acute physical trauma and physiological stress. To cope with this, it …

Repair of damaged skeletal‐muscle tissue is limited by the regenerative capacity of the
native tissue. Current clinical approaches are not optimal for the treatment of large …

Recent discoveries reveal complex interactions between skeletal muscle and the immune
system that regulate muscle regeneration. In this review, we evaluate evidence that …

Satellite cells are tissue resident muscle stem cells required for postnatal skeletal muscle
growth and repair through replacement of damaged myofibers. Muscle regeneration is …

Distinct cell populations with regenerative capacity have been reported to contribute to
myofibres after skeletal muscle injury, including non-satellite cells as well as myogenic …

Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both
hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic …