Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice

H Zheng, P Xu, Q Jiang, Q Xu, Y Zheng, J Yan, H Ji… - Microbiome, 2021 - Springer
Background Modification of the gut microbiota has been reported to reduce the incidence of
type 1 diabetes mellitus (T1D). We hypothesized that the gut microbiota shifts might also …

Microvascular basis of cognitive impairment in type 1 diabetes

S Sharma, CE Brown - Pharmacology & Therapeutics, 2022 - Elsevier
The complex computations of the brain require a constant supply of blood flow to meet its
immense metabolic needs. Perturbations in blood supply, even in the smallest vascular …

Case report: Ketogenic diet alleviated anxiety and depression associated with insulin-dependent diabetes management

E Winje, I Lake, SN Dankel - Frontiers in Nutrition, 2024 - frontiersin.org
Differentiating between an irrational versus a rational fear of hypoglycemia has treatment
implications and presents significant challenge for clinicians facing patients with type 1 …

Alterations in functional connectivity of thalamus and primary somatosensory cortex in painful and painless diabetic peripheral neuropathy

SS Croosu, J Røikjer, CD Mørch, N Ejskjaer… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE In this study we aimed to investigate the functional connectivity of brain regions
involved in sensory processing in diabetes with and without painful and painless diabetic …

[PDF][PDF] Network medicine-based epistasis detection in complex diseases: ready for quantum computing

M Hoffmann, JM Poschenrieder, M Incudini… - Nucleic Acids …, 2024 - academic.oup.com
Most heritable diseases are polygenic. To comprehend the underlying genetic architecture,
it is crucial to discover the clinically relevant epistatic interactions (EIs) between genomic …

Transplant of fecal microbiota from healthy young mice relieves cognitive defects in late-stage diabetic mice by reducing metabolic disorders and neuroinflammation

X Ye, Q Jiang, M Wu, Q Ye, H Zheng - Acta Pharmacologica Sinica, 2024 - nature.com
Fecal microbiota transplant (FMT) is becoming as a promising area of interest for treating
refractory diseases. In this study, we investigated the effects of FMT on diabetes-associated …

Different FreeSurfer versions might generate different statistical outcomes in case–control comparison studies

P Filip, P Bednarik, LE Eberly, A Moheet, A Svatkova… - Neuroradiology, 2022 - Springer
Purpose Neuroimaging pipelines have long been known to generate mildly differing results
depending on various factors, including software version. While considered generally …

Gray matter brain alterations in type 1 diabetes–findings based on detailed phenoty** of neuropathy status

SS Croosu, TM Hansen, J Røikjer… - Experimental and …, 2022 - thieme-connect.com
Aims This study investigated brain structure in patients of type 1 diabetes with diabetic
peripheral neuropathy (DPN) and type 1 diabetes with neuropathic pain and the …

[HTML][HTML] Altered surface-based brain morphometry in type 1 diabetes and neuropathic pain

SNF Hostrup, SS Croosu, J Røikjer, CD Mørch… - Neuroscience, 2025 - Elsevier
This study explored surface brain morphometry in type 1 diabetes including focus on painful
diabetic peripheral neuropathy (DPN). Brain MRI was obtained from 56 individuals with …

[HTML][HTML] Altered functional connectivity between brain structures in adults with type 1 diabetes and polyneuropathy

SS Croosu, TM Hansen, B Brock, AM Drewes, C Brock… - Brain Research, 2022 - Elsevier
Objective Alterations of the central nervous system are increasingly being recognized as a
part of diabetes, especially in the thalamus and the default mode network (DMN). However …