Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways

R Zhang, C Bian, J Gao, H Ren - Apoptosis, 2023 - Springer
Diabetes kidney disease (DKD) is one of the common chronic microvascular complications
of diabetes, which has become the most important cause of modern chronic kidney disease …

Genetic disruption of mammalian endoplasmic reticulum‐associated protein degradation: Human phenotypes and animal and cellular disease models

S Badawi, FE Mohamed, DS Varghese, BR Ali - Traffic, 2023 - Wiley Online Library
Endoplasmic reticulum‐associated protein degradation (ERAD) is a stringent quality control
mechanism through which misfolded, unassembled and some native proteins are targeted …

Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress

R Kandel, J Jung, D Syau, T Kuo, L Songster… - Plos …, 2023 - journals.plos.org
Protein aggregates are a common feature of diseased and aged cells. Membrane proteins
comprise a quarter of the proteome, and yet, it is not well understood how aggregation of …

[HTML][HTML] The role of rhomboid superfamily members in protein homeostasis: Mechanistic insight and physiological implications

RR Kandel, SE Neal - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Cells are equipped with protein quality control pathways in order to maintain a healthy
proteome; a process known as protein homeostasis. Dysfunction in protein homeostasis …

Suppressed ER‐associated degradation by intraglomerular cross talk between mesangial cells and podocytes causes podocyte injury in diabetic kidney disease

D Fujimoto, T Kuwabara, Y Hata, S Umemoto… - The FASEB …, 2020 - Wiley Online Library
Mesangial lesions and podocyte injury are essential manifestations of the progression of
diabetic kidney disease (DKD). Although cross‐communication between mesangial cells …

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

VG Volpi, C Ferri, I Fregno, U Del Carro, F Bianchi… - PLoS …, 2019 - journals.plos.org
In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large
amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral …

The role of the rhomboid superfamily in ER protein quality control: From mechanisms and functions to diseases

S Bhaduri, NA Scott, SE Neal - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells and is a major
site for protein folding, modification, and lipid synthesis. Perturbations within the ER, such as …

[HTML][HTML] Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid

KJ Won, JS Park, H Jeong - Journal of lipid research, 2019 - Elsevier
All-trans retinoic acid (atRA) is used to treat certain cancers and dermatologic diseases. A
common adverse effect of atRA is hypercholesterolemia; cytochrome P450 (CYP) 7A …

A novel VCP modulator KUS121 exerts renoprotective effects in ischemia-reperfusion injury with retaining ATP and restoring ERAD-processing capacity

Y Hata, R Date, D Fujimoto, HO Ikeda… - American Journal …, 2022 - journals.physiology.org
Acute kidney injury (AKI) is a life-threatening condition and often progresses to chronic
kidney disease or the development of other organ dysfunction even after recovery. Despite …

Starvation Induces endoplasmic reticulum stress and autophagy in malpighian tubules of two-spotted field crickets gryllus bimaculatus

N Lee, JH Song, Y Ko, K Kwon, ER Lee… - Journal of the Kansas …, 2020 - BioOne
We investigated gene expression related to endoplasmic reticulum (ER) stress, apoptosis,
and autophagy to understand how Gryllus bimaculatus (two-spotted field cricket) overcomes …