Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …

The remodelling of replication forks into four-way junctions following replication perturbation,
known as fork reversal, was hypothesized to promote DNA damage tolerance and repair …

Standard CRISPR-mediated gene disruption strategies rely on Cas9-induced DNA double-
strand breaks (DSBs). Here, we show that CRISPR-dependent base editing efficiently …

Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor
rejection. However, cancer cells often evade these responses by overexpressing immune …

DNA replication stress can stall replication forks, leading to genome instability. DNA damage
tolerance pathways assist fork progression, promoting replication fork reversal, translesion …

Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit
genetic information to our offspring as well as our own survival. To respond to these threats …

To ensure the completion of DNA replication and maintenance of genome integrity, DNA
repair factors protect stalled replication forks upon replication stress. Previous studies have …

Abstract The Replication Protein A (RPA) complex is an essential regulator of eukaryotic
DNA metabolism. RPA avidly binds to single-stranded DNA (ssDNA) through multiple …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

The DNA damage response kinase ataxia telangiectasia and Rad3-related (ATR)
coordinates much of the cellular response to replication stress. The exact mechanisms by …