In this review, we describe the recent advances in supramolecular helical assemblies
formed from chiral and achiral small molecules, oligomers (foldamers), and helical and …

The art of transforming peptides into drug leads is still a dynamic and fertile field in medicinal
chemistry and drug discovery. Peptidomimetics can respond to peptide limitations by …

The primary sequence of a biopolymer encodes the essential information for folding,
permitting to carry out sophisticated functions. Inspired by natural biopolymers, peptide and …

The widespread use of molecular machines in biology has long suggested that great
rewards could come from bridging the gap between synthetic molecular systems and the …

Complex chemical systems, such as living biological matter, are highly organized structures
based on discrete molecules in constant dynamic interactions. These natural materials can …

The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

Synthetic dynamic helical polymers (supramolecular and covalent) and foldamers share the
helix as a structural motif. Although the materials are different, these systems also share …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Background During the last few decades, progress has been made in manipulating the
architecture of synthetic polymer materials. However, the primary structure—that is, the …

In the realm of particle self-assembly, it is possible to reliably construct nearly arbitrary
structures if all the pieces are distinct,–, but systems with fewer flavours of building blocks …