The acid-base characteristics of tumor cells and the other elements that compose the tumor
microenvironment have been topics of scientific interest in oncological research. There is …

Hv1 is the only voltage-gated proton-selective channel in mammalian cells. It contains a
conserved voltage-sensor domain, shared by a large class of voltage-gated ion channels …

ATP is an important molecule implicated in diverse biochemical processes, including the
modulation of ion channel and transporter activity. The voltage‐gated proton channel (Hv1) …

The human voltage-gated proton channel (HV1) provides an efficient proton extrusion
pathway from the cytoplasm contributing to the intracellular pH regulation and the oxidative …

The voltage-gated hydrogen channel Hv1 encoded in humans by the HVCN1 gene is a
highly selective proton channel that allows large fluxes of protons across biological …

Living organisms are multiscale complex systems that have evolved high degrees of
multifunctionality and redundancy in the structure–function relationship. A number of factors …

The voltage-gated proton channel HVCN1 is a member of the voltage-gated ion channel
family. HVCN1 channel controls acid extrusion and regulates pH homeostasis in various cell …

The human voltage-gated proton channel (hHv1) is a highly selective ion channel codified
by the HVCN1 gene. It plays a fundamental role in several physiological processes such as …

The voltage-gated proton channel Hv1 mediates efflux of protons from the cell. Hv1
integrally contributes to various physiological processes including pH homeostasis and the …

Voltage‐gated proton channels (HV1) have been found in many mammalian cells and play
a crucial role in the immune system, male fertility, and cancer progression …