Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Obesity is widely acknowledged as a risk factor for both the incidence and progression of
osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body …

Osteoarthritis (OA) may result from intrinsic inflammation related to metabolic disturbance.
Obesity-associated inflammation is triggered by lipopolysaccharide (LPS) derived from the …

Recent studies have shown that overweight and obesity play an important role in the
development of osteoarthritis (OA). However, joint overload is not the only risk factor in this …

OA is a complex disease involving mechanical, metabolic and inflammatory contributions to
its aetiology. A key risk factor, obesity, is becoming an increasing focus of research due to its …

Rheumatic diseases encompass a diverse group of chronic disorders that commonly affect
musculoskeletal structures. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two …

Knee osteoarthritis, the most prevalent degenerative joint disorder worldwide, is driven by
chronic low‐grade inflammation and subsequent cartilage degradation. Clinical data on the …

Adipose tissue secretes highly bioactive factors, the adipokines. Systemic levels of
adipokines are often altered in the presence of inflammation. In turn, adipokines affect …

Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration. It is
a whole organ disease characterized by cartilage degeneration and varying degrees of …

Abstract Purpose of the Review Osteoarthritis (OA) is a chronic, painful joint disease that
affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while …