In-depth Mechanism, Challenges, and Opportunities of Delivering Therapeutics in Brain Using...

PLGA Nanoparticles Based Mucoadhesive Nasal In Situ Gel for Enhanced Brain Delivery of Topiramate

V Tanna, A Vora, P Shah, AB Nair, J Shah… - AAPS …, 2024 - Springer
Oral Topiramate therapy is associated with systemic adverse effects including paresthesia,
abdominal pain, and fluctuations in plasma levels. The purpose of this research was to …
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[PDF] biorxiv.org

Cav3. 1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss

AH Tsang, N Heeley, C Alcaino, E Hwang, BY Lam… - bioRxiv, 2024 - biorxiv.org
Hypothalamic leucine sensing promotes satiety and weight loss but an understanding of
how leucine regulates neuronal activity is lacking. Here we show that Cacna1g, encoding …
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