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Role of inositols and inositol phosphates in energy metabolism
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as
phytic acid or IP6, with their biological activities received much attention for their role in …
phytic acid or IP6, with their biological activities received much attention for their role in …
Myo-inositol and D-chiro-inositol as modulators of ovary steroidogenesis: A narrative review
Myo-inositol is a natural polyol, the most abundant among the nine possible structural
isomers available in living organisms. Inositol confers some distinctive traits that allow for a …
isomers available in living organisms. Inositol confers some distinctive traits that allow for a …
Development of novel IP6K inhibitors for the treatment of obesity and obesity-induced metabolic dysfunctions
Obesity and obesity-induced metabolic dysfunctions are significant risk factors for
nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic …
nonalcoholic fatty liver disease and cardiovascular diseases. Thus, obesity is an economic …
[HTML][HTML] Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling
J Qi, W Cheng, Z Gao, Y Chen, ML Shipton… - Biomedicine & …, 2023 - Elsevier
The antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the
mechanisms of action have been elusive. Here we report that itraconazole disrupts focal …
mechanisms of action have been elusive. Here we report that itraconazole disrupts focal …
Inositol pyrophosphates: signaling molecules with pleiotropic actions in mammals
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7)
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …
Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2
H Li, M Datunashvili, RC Reyes… - Frontiers in Cellular …, 2022 - frontiersin.org
Inositol pyrophosphates have been implicated in cellular signaling and membrane
trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases …
trafficking, including synaptic vesicle (SV) recycling. Inositol hexakisphosphate kinases …
[HTML][HTML] Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein AI
X Liu, Z Zhang, T Aguirre, ML Shipton, L Fu, J Du… - Metabolism, 2025 - Elsevier
Background and aims Atherosclerotic cardiovascular diseases are the leading cause of
death. Apolipoprotein AI (apoA-I) mediates cholesterol efflux to lower the risks of …
death. Apolipoprotein AI (apoA-I) mediates cholesterol efflux to lower the risks of …
Enhancing health and therapeutic potential: innovations in the medicinal and pharmaceutical properties of soy bioactive compounds
An extensive examination of the medical uses of soybean bioactive components is provided
by this thorough review. It explores the possible health advantages of isoflavones with …
by this thorough review. It explores the possible health advantages of isoflavones with …
[HTML][HTML] The inositol pyrophosphate metabolism of Dictyostelium discoideum does not regulate inorganic polyphosphate (polyP) synthesis
Y Desfougères, P Portela-Torres, D Qiu… - Advances in Biological …, 2022 - Elsevier
Initial studies on the inositol phosphates metabolism were enabled by the social amoeba
Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP 6 also …
Dictyostelium discoideum. The abundant amount of inositol hexakisphosphate (IP 6 also …
Phenolic compounds as α-glucosidase inhibitors: A docking and molecular dynamics simulation study
Phenolic compounds possess significant biological activity. Several pieces of research
emphasize the medicinal importance of phenolic compounds, including diabetes. The …
emphasize the medicinal importance of phenolic compounds, including diabetes. The …