Neoadjuvant therapy for pancreatic cancer

C Springfeld, CR Ferrone, MHG Katz… - Nature Reviews …, 2023 - nature.com
Patients with localized pancreatic ductal adenocarcinoma (PDAC) are best treated with
surgical resection of the primary tumour and systemic chemotherapy, which provides …

Pancreatic cancer: a review of current treatment and novel therapies

HM Kolbeinsson, S Chandana, GP Wright… - Journal of Investigative …, 2023 - Taylor & Francis
Pancreatic cancer is one of the leading causes for cancer-related deaths in the United
States. Majority of patients present with unresectable or metastatic disease. For those that …

Efficacy of preoperative mFOLFIRINOX vs mFOLFIRINOX plus hypofractionated radiotherapy for borderline resectable adenocarcinoma of the pancreas: the A021501 …

MHG Katz, Q Shi, J Meyers, JM Herman… - JAMA …, 2022 - jamanetwork.com
Importance National guidelines endorse treatment with neoadjuvant therapy for borderline
resectable pancreatic ductal adenocarcinoma (PDAC), but the optimal strategy remains …

Pancreatic cancer stroma: an update on therapeutic targeting strategies

AN Hosein, RA Brekken, A Maitra - Nature reviews Gastroenterology & …, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch randomized phase III …

E Versteijne, M Suker, K Groothuis… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Preoperative chemoradiotherapy may improve the radical resection rate for
resectable or borderline resectable pancreatic cancer, but the overall benefit is unproven …

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

AJ Grossberg, LC Chu, CR Deig… - CA: a cancer journal …, 2020 - Wiley Online Library
Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer,
the prognosis for this disease remains very poor, largely because of delayed disease …

Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

M Orth, P Metzger, S Gerum, J Mayerle, G Schneider… - Radiation …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …

[HTML][HTML] Early detection of pancreatic cancer: opportunities and challenges

AD Singhi, EJ Koay, ST Chari, A Maitra - Gastroenterology, 2019 - Elsevier
Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …

Total neoadjuvant therapy with FOLFIRINOX in combination with losartan followed by chemoradiotherapy for locally advanced pancreatic cancer: a phase 2 clinical …

JE Murphy, JY Wo, DP Ryan, JW Clark, W Jiang… - JAMA …, 2019 - jamanetwork.com
Importance Patients with locally advanced pancreatic cancer have historically poor
outcomes. Evaluation of a total neoadjuvant approach is warranted. Objective To evaluate …

[HTML][HTML] Factors predicting response, perioperative outcomes, and survival following total neoadjuvant therapy for borderline/locally advanced pancreatic cancer

MJ Truty, ML Kendrick, DM Nagorney, RL Smoot… - Annals of …, 2021 - journals.lww.com
Objective: To identify predictive factors associated with operative morbidity, mortality, and
survival outcomes in patients with borderline resectable (BR) or locally advanced (LA) …