Neoadjuvant therapy for pancreatic cancer
Patients with localized pancreatic ductal adenocarcinoma (PDAC) are best treated with
surgical resection of the primary tumour and systemic chemotherapy, which provides …
surgical resection of the primary tumour and systemic chemotherapy, which provides …
Pancreatic cancer: a review of current treatment and novel therapies
HM Kolbeinsson, S Chandana, GP Wright… - Journal of Investigative …, 2023 - Taylor & Francis
Pancreatic cancer is one of the leading causes for cancer-related deaths in the United
States. Majority of patients present with unresectable or metastatic disease. For those that …
States. Majority of patients present with unresectable or metastatic disease. For those that …
Efficacy of preoperative mFOLFIRINOX vs mFOLFIRINOX plus hypofractionated radiotherapy for borderline resectable adenocarcinoma of the pancreas: the A021501 …
Importance National guidelines endorse treatment with neoadjuvant therapy for borderline
resectable pancreatic ductal adenocarcinoma (PDAC), but the optimal strategy remains …
resectable pancreatic ductal adenocarcinoma (PDAC), but the optimal strategy remains …
Pancreatic cancer stroma: an update on therapeutic targeting strategies
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …
the Western world with limited therapeutic options and dismal long-term survival. The …
Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch randomized phase III …
E Versteijne, M Suker, K Groothuis… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Preoperative chemoradiotherapy may improve the radical resection rate for
resectable or borderline resectable pancreatic cancer, but the overall benefit is unproven …
resectable or borderline resectable pancreatic cancer, but the overall benefit is unproven …
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma
Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer,
the prognosis for this disease remains very poor, largely because of delayed disease …
the prognosis for this disease remains very poor, largely because of delayed disease …
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …
[HTML][HTML] Early detection of pancreatic cancer: opportunities and challenges
Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …
Total neoadjuvant therapy with FOLFIRINOX in combination with losartan followed by chemoradiotherapy for locally advanced pancreatic cancer: a phase 2 clinical …
JE Murphy, JY Wo, DP Ryan, JW Clark, W Jiang… - JAMA …, 2019 - jamanetwork.com
Importance Patients with locally advanced pancreatic cancer have historically poor
outcomes. Evaluation of a total neoadjuvant approach is warranted. Objective To evaluate …
outcomes. Evaluation of a total neoadjuvant approach is warranted. Objective To evaluate …
[HTML][HTML] Factors predicting response, perioperative outcomes, and survival following total neoadjuvant therapy for borderline/locally advanced pancreatic cancer
Objective: To identify predictive factors associated with operative morbidity, mortality, and
survival outcomes in patients with borderline resectable (BR) or locally advanced (LA) …
survival outcomes in patients with borderline resectable (BR) or locally advanced (LA) …