Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Carbon nanomaterials are a class of low-dimensional materials that have aroused a great
deal of interest in the past 30 years since the spectacular debut of fullerene, the first member …

Fluorescent calcium sensors are widely used to image neural activity. Using structure-based
mutagenesis and neuron-based screening, we developed a family of ultrasensitive protein …

This highly influential work--now in a revised and expanded third edition incorporating major
advances in the field--gives clinicians, educators, and students a new understanding of what …

Microglial cells represent the immune system of the mammalian brain and therefore are
critically involved in various injuries and diseases. Little is known about their role in the …

Two extant frameworks–the harshness-unpredictability model and the threat-deprivation
model–attempt to explain which dimensions of adversity have distinct influences on …

With few exceptions biological tissues strongly scatter light, making high-resolution deep
imaging impossible for traditional—including confocal—fluorescence microscopy. Nonlinear …

Synapses between engram cells are believed to be substrates for memory storage, and the
weakening or loss of these synapses leads to the forgetting of related memories. We found …

Does the structure of an adult human brain alter in response to environmental demands,?
Here we use whole-brain magnetic-resonance imaging to visualize learning-induced …

Dendritic spines of pyramidal neurons in the cerebral cortex undergo activity-dependent
structural remodelling,,,, that has been proposed to be a cellular basis of learning and …