Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

Proteasome is a multi-protein organelle that participates in cellular proteostasis by
destroying damaged or short-lived proteins in an organized manner guided by the …

Identifying master regulators of biological processes and map** their downstream gene
networks are key challenges in systems biology. We developed a computational method …

Cellular senescence is a stress response of human cells that removes potentially harmful
cells by initiating cell cycle arrest. Inducing senescence of tumor cells may be an effective …

Cellular senescence, a term originally used to define the characteristics of normal human
fibroblasts that reached their replicative limit, is an important factor for ageing, age-related …

Prognostication is a key issue for sarcoma patients' care as it triggers the therapeutic
approach including chemotherapy, which is still not standard for localized patients. Current …

Totipotency of embryonic stem cells (ESCs) is controlled at the transcriptional level by a
handful of transcription factors (TFs) that promote stemness and prevent differentiation. One …

Hematopoietic stem cells (HSCs) are characterized by the ability to self-renew and to
replenish the hematopoietic system. The cell-cycle kinase cyclin-dependent kinase 6 …

p63 is a transcriptional factor implicated in cancer and development. The presence in TP63
gene of alternative promoters allows expression of one isoform containing the N-terminal …

Abstract p63 is a p53 family transcription factor, which besides unique roles in epithelial
development, shares tumor suppressive activity with its homolog p53. The p63 gene has …