Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Physical challenges, emotional arousal, increased physical activity, or changes in the
environment can evoke stress, requiring altered activity of visceral organs, glands, and …

Members of the heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptor (GPCR) family play key roles in many physiological functions and are extensively …

Heart failure is a leading cause of mortality in the United States. As a result of advances in
genetic technology, a molecular basis of heart failure is emerging. 1, 2 This review highlights …

Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …

Abstract The PTEN/PI3K signaling pathway regulates a vast array of fundamental cellular
responses. We show that cardiomyocyte-specific inactivation of tumor suppressor PTEN …

G protein-coupled receptors (GPCRs) are critical cellular sensors that mediate numerous
physiological processes. In the heart, multiple GPCRs are expressed on various cell types …

Sepsis is a systemic inflammatory response that follows bacterial infection. Cardiac
dysfunction is an important consequence of sepsis that affects mortality and has been …

Background—β-Adrenergic receptor (β-AR) stimulation increases apoptosis in adult rat
cardiac (ventricular) myocytes (ARVMs) via activation of adenylyl cyclase. β2-ARs may …

The importance of β-adrenergic signaling in the heart has been well documented, but it is
only more recently that we have begun to understand the importance of this signaling …