Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and
devastating septicemia. Although effective vaccines exist for several serogroups of …

This paper reviews the current status of research and development of vaccines against
meningococcal disease due to Neisseria meningitidis, a major cause of severe meningitis …

Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that
still cause significant mortality. To date there is no universal vaccine that prevents these …

Neisseria meningitidis binds factor H (fH), a key regulator of the alternative complement
pathway. A∼ 29 kD fH-binding protein expressed in the meningococcal outer membrane …

The complement system is an essential component of the innate and acquired immune
system, and consists of a series of proteolytic cascades that are initiated by the presence of …

Technology platforms are an important strategy to facilitate the design, development and
implementation of vaccines to combat high-burden diseases that are still a threat for human …

Map** of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for
understanding the nature of immune responses and designing improved vaccines …

The sequence variability of protective antigens is a major challenge to the development of
vaccines. For Neisseria meningitidis, the bacterial pathogen that causes meningitis, the …

Epitope map** of antibodies (Abs) is crucial for understanding adaptive immunity, as well
as studying the mode of action of therapeutic antibodies and vaccines. Especially insights …

Certain pathogens recruit host complement inhibitors such as factor H (fH) to evade the
immune system. Microbial complement inhibitor-binding molecules can be promising …