Cyclooxygenase‐2 in cancer: a review
Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …
Antitumour immunity regulated by aberrant ERBB family signalling
S Kumagai, S Koyama, H Nishikawa - Nature Reviews Cancer, 2021 - nature.com
Aberrant signalling of ERBB family members plays an important role in tumorigenesis and in
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
the escape from antitumour immunity in multiple malignancies. Molecular-targeted agents …
Inflammation-induced tumorigenesis and metastasis
S Hibino, T Kawazoe, H Kasahara, S Itoh… - International journal of …, 2021 - mdpi.com
Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …
Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges
Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …
pathways due to the acquisition of genetic and epigenetic changes. An array of growth …
Inflammatory breast cancer biology: the tumour microenvironment is key
Inflammatory breast cancer (IBC) is a rare and aggressive disease that accounts for~ 2–4%
of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10 …
of all breast cancers. However, despite its low incidence rate, IBC is responsible for 7–10 …
EGFR is a master switch between immunosuppressive and immunoactive tumor microenvironment in inflammatory breast cancer
Inflammatory breast cancer (IBC), the most aggressive breast cancer subtype, is driven by
an immunosuppressive tumor microenvironment (TME). Current treatments for IBC have …
an immunosuppressive tumor microenvironment (TME). Current treatments for IBC have …
EGFR: An essential receptor tyrosine kinase-regulator of cancer stem cells
S Talukdar, L Emdad, SK Das, PB Fisher - Advances in cancer research, 2020 - Elsevier
Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated
levels in different forms of cancer and expression often correlates positively with cancer …
levels in different forms of cancer and expression often correlates positively with cancer …
Inflammatory breast cancer promotes development of M2 tumor-associated macrophages and cancer mesenchymal cells through a complex chemokine network
Inflammatory breast cancer (IBC) is a highly aggressive form of breast cancer that displays
profound cancer stem cell (CSC) and mesenchymal features that promote rapid metastasis …
profound cancer stem cell (CSC) and mesenchymal features that promote rapid metastasis …
Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer
Inflammatory breast cancer (IBC) is a clinically distinct and highly aggressive form of breast
cancer with rapid onset and a strong propensity to metastasize. The molecular mechanisms …
cancer with rapid onset and a strong propensity to metastasize. The molecular mechanisms …
Targeting cancer stem cells in the clinic: Current status and perspectives
Resistance to chemotherapy and cancer relapse are major clinical challenges attributed to a
sub population of cancer stem cells (CSCs). The concept of CSCs has been the subject of …
sub population of cancer stem cells (CSCs). The concept of CSCs has been the subject of …