Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Regular exercise is a formidable regulator of insulin sensitivity and overall systemic
metabolism through both acute events driven by each exercise bout and through chronic …

The interaction between insulin and exercise is an example of balancing and modifying the
effects of two opposing metabolic regulatory forces under varying conditions. While insulin is …

The endothelial cell response to glucose plays an important role in both health and disease.
Endothelial glucose-induced dysfunction was first studied in diabetic animal models and in …

The glucose transporter GLUT4 is critical for skeletal muscle glucose uptake in response to
insulin and muscle contraction/exercise. Exercise increases GLUT4 translocation to the …

Exercise in humans increases muscle glucose uptake up to 100-fold compared with rest.
The magnitude of increase depends on exercise intensity and duration. Although knockout …

Exercise is a powerful driver of physiological angiogenesis during adulthood, but the
mechanisms of exercise-induced vascular expansion are poorly understood. We explored …

Sufficient delivery of oxygen and metabolic substrates, together with removal of waste
products, are key elements of muscle performance. Capillaries are the primary site for this …

Endothelial cells (ECs) not only form passive blood conduits but actively contribute to
nutrient transport and organ homeostasis. The role of ECs in glucose homeostasis is …