[HTML][HTML] Stress and telomere shortening: Insights from cellular mechanisms
J Lin, E Epel - Ageing research reviews, 2022 - Elsevier
Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …
to disease through many pathways, and research from in vitro studies to human longitudinal …
Sex differences in biological aging with a focus on human studies
S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
Polygenic basis and biomedical consequences of telomere length variation
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …
senescence. Here we characterize the genetic architecture of naturally occurring variation in …
Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank
Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …
Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …
Thymidine nucleotide metabolism controls human telomere length
W Mannherz, S Agarwal - Nature genetics, 2023 - nature.com
Telomere length in humans is associated with lifespan and severe diseases, yet the genetic
determinants of telomere length remain incompletely defined. Here we performed genome …
determinants of telomere length remain incompletely defined. Here we performed genome …
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …
Telomeres, aging, and cancer: the big picture
PM Lansdorp - Blood, The Journal of the American Society of …, 2022 - ashpublications.org
The role of telomeres in human health and disease is yet to be fully understood. The
limitations of mouse models for the study of human telomere biology and difficulties in …
limitations of mouse models for the study of human telomere biology and difficulties in …
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
Genetic studies on telomere length are important for understanding age-related diseases.
Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here …
Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here …
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential
Human genetic studies support an inverse causal relationship between leukocyte telomere
length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and …
length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and …