Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Aging is a complex biological process characterized by hallmark features accumulating over
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …

Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …

Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …

Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …

Telomere length in humans is associated with lifespan and severe diseases, yet the genetic
determinants of telomere length remain incompletely defined. Here we performed genome …

Early-life tobacco exposure serves as a non-negligible risk factor for aging-related diseases.
To understand the underlying mechanisms, we explored the associations of early-life …

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …

The role of telomeres in human health and disease is yet to be fully understood. The
limitations of mouse models for the study of human telomere biology and difficulties in …

Emerging evidence has shown that leukocyte telomere length (LTL) is associated with
various health‐related outcomes, while the causality of these associations remains unclear …