P-glycoprotein: New insights into structure, physiological function, regulation and alterations in disease
The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …
industry. This resistance is a common occurrence in several diseases and is mediated by …
Drug-resistant epilepsy: multiple hypotheses, few answers
Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …
ABC transporter-mediated multidrug-resistant cancer
ATP-binding cassette (ABC) transporters are involved in active pum** of many diverse
substrates through the cellular membrane. The transport mediated by these proteins …
substrates through the cellular membrane. The transport mediated by these proteins …
ABCB1 and ABCG2 regulation at the blood-brain barrier: potential new targets to improve brain drug delivery
The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …
Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis
QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
Pharmacoresistance–Epidemiology, mechanisms, and impact on epilepsy treatment
M Janmohamed, MJ Brodie, P Kwan - Neuropharmacology, 2020 - Elsevier
Understanding the natural history of and factors associated with pharmacoresistant epilepsy
provides the foundation for formulating mechanistic hypotheses that can be evaluated to …
provides the foundation for formulating mechanistic hypotheses that can be evaluated to …
Key factors in the discovery and development of new antiepileptic drugs
M Bialer, HS White - Nature reviews Drug discovery, 2010 - nature.com
Since the early 1990s, many new antiepileptic drugs (AEDs) that offer appreciable
advantages in terms of their favourable pharmacokinetics, improved tolerability and lower …
advantages in terms of their favourable pharmacokinetics, improved tolerability and lower …
Blood–brain barrier leakage may lead to progression of temporal lobe epilepsy
EA Van Vliet, S da Costa Araújo, S Redeker… - Brain, 2007 - academic.oup.com
Leakage of the blood–brain barrier (BBB) is associated with various neurological disorders,
including temporal lobe epilepsy (TLE). However, it is not known whether alterations of the …
including temporal lobe epilepsy (TLE). However, it is not known whether alterations of the …
Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
The strength of the blood-brain barrier (BBB) in providing protection to the central nervous
system from exposure to circulating chemicals is maintained by tight junctions between …
system from exposure to circulating chemicals is maintained by tight junctions between …
Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Epilepsy, a common multifactorial neurological disease, affects about 69 million people
worldwide constituting nearly 1% of the world population. Despite decades of extensive …
worldwide constituting nearly 1% of the world population. Despite decades of extensive …