The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

The human mitochondrial genome is extremely small compared with the nuclear genome,
and mitochondrial genetics presents unique clinical and experimental challenges. Despite …

As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …

Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic
inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome …

Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

We are witnessing a period of renewed interest in the biology of the mitochondrion. The
mitochondrion serves a critical function in the maintenance of cellular energy stores …

Altered expression of mitochondrial DNA (mtDNA) occurs in ageing and a range of human
pathologies (for example, inborn errors of metabolism, neurodegeneration and cancer) …

Although the concept of energy starvation in the failing heart was proposed decades ago,
still very little is known about the origin of energetic failure. Recent advances in molecular …

Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the
inner membrane of the organelle are involved in the oxidative phosphorylation required for …