Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
[HTML][HTML] Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
S Ma, J Li, L Pei, N Feng, Y Zhang - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may
therefore substitute blood in drug analysis. However, current ISF extraction techniques …
therefore substitute blood in drug analysis. However, current ISF extraction techniques …
Developmental cell programs are co-opted in inflammatory skin disease
G Reynolds, P Vegh, J Fletcher, EFM Poyner… - Science, 2021 - science.org
INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …
insult through structural adaptations and interplay with the innate and adaptive immune …
Dysregulation of the epithelial barrier by environmental and other exogenous factors
The “epithelial barrier hypothesis” proposes that the exposure to various epithelial barrier–
damaging agents linked to industrialization and urbanization underlies the increase in …
damaging agents linked to industrialization and urbanization underlies the increase in …
Classification of human chronic inflammatory skin disease based on single-cell immune profiling
Inflammatory conditions represent the largest class of chronic skin disease, but the
molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA …
molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA …
TREM2 macrophages induced by human lipids drive inflammation in acne lesions
Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …
Proximity extension assay in combination with next-generation sequencing for high-throughput proteome-wide analysis
L Wik, N Nordberg, J Broberg, J Björkesten… - Molecular & Cellular …, 2021 - ASBMB
Understanding the dynamics of the human proteome is crucial for develo** biomarkers to
be used as measurable indicators for disease severity and progression, patient stratification …
be used as measurable indicators for disease severity and progression, patient stratification …
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization
The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral
environments remain mostly undefined. We show that differentiation of CD11blo migratory …
environments remain mostly undefined. We show that differentiation of CD11blo migratory …
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade
Therapeutic options for autoimmune diseases typically consist of broad and targeted
immunosuppressive agents. However, sustained clinical benefit is rarely achieved, as the …
immunosuppressive agents. However, sustained clinical benefit is rarely achieved, as the …
scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in Treg function
KJ Gellatly, JP Strassner, K Essien, MA Refat… - Science translational …, 2021 - science.org
Vitiligo is an autoimmune skin disease characterized by the targeted destruction of
melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in …
melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in …