Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may
therefore substitute blood in drug analysis. However, current ISF extraction techniques …

Mast cells (MCs) are widely recognized as central effector cells during type 2 inflammatory
reactions and thought to also play a role in innate immune responses, wound healing, and …

Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …

INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …

Inflammatory conditions represent the largest class of chronic skin disease, but the
molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA …

Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …

Understanding the dynamics of the human proteome is crucial for develo** biomarkers to
be used as measurable indicators for disease severity and progression, patient stratification …

Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease
with complex pathogenesis for which the cellular and molecular crosstalk in AD skin has not …

The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral
environments remain mostly undefined. We show that differentiation of CD11blo migratory …

Abundant heterogeneous immune cells infiltrate lesions in chronic inflammatory diseases
and characterization of these cells is needed to distinguish disease-promoting from …